Reproductive late effects and testosterone replacement therapy in male childhood cancer survivors: A population-based study (the Fex-Can study)

Nowadays, most children with cancer survive, but many experience long-term effects from their cancer treatment. Treatments like conditioning therapy for hematopoietic stem cell transplantation, high cumulative doses of alkylating agents and radiation can damage the gonads, leading to problems such as infertility and delayed puberty in males. Identifying and addressing these issues in follow-up care …

Read more

Tête-à-tête with Aurore Roland

Meet Aurore Roland, our guide into the science behind good sleep at the upcoming 16th NYRA Meeting in Brussels (May 27th-29th). Dra. Aurore Roland obtained her master’s degree in clinical psychology from the Vrije Universiteit Brussel (VUB) in 2021. The same year she became a European Sleep Research Society-certified expert in behavioural sleep medicine. She …

Read more

Tête-à-tête with Sarah Martins Da Silva

Dr Sarah Martins da Silva is a Consultant Gynaecologist based at Ninewells Assisted Conception Unit, Ninewells Hospital Dundee. She is experienced in all aspects of subfertility investigation and management. Dr Martins da Silva qualified in 1995. During her specialist training she completed MD investigating various aspects of ovarian development and egg maturation (University of Edinburgh …

Read more

Tête-à-tête with Herman Tournaye

Get to know Dr Herman Tournaye, one of the invited speakers to the upcoming 16th NYRA Meeting in Brussels (May 27th-29th), through this interview. Prof. Tournaye is the Medical and Scientific Director of Brussels IVF and a Professor at the Vrije Universiteit Brussel (VUB). His research focuses on spermatogenesis and testicular stem cells. When and why …

Read more

Tête-à-tête with Callista Mulder

Photo taken by Martijn Gijsbertsen

Portrait by Martijn Gijsbertsen. Get to know Dr Callista Mulder, one of the invited speakers to the upcoming 16th NYRA Meeting in Brussels (May 27th-29th), through this interview. Dr Callista Mulder is based at Amsterdam UMC in the Netherlands. Her research focuses on the development of safe and effective reproductive therapies for individuals facing challenges …

Read more

Sperm Toolbox & why we needed it

In recent years, our knowledge about male reproductive health has made big advances. However, two main questions still remain unanswered: ‘When will we have an effective male contraceptive pill?’ and ‘Can we cure patients with abnormal spermiogram parameters?’ A recent study by Gruber et al. (https://doi.org/10.1371/journal.pone.0297666) brings us a step closer to answering both questions. …

Read more

Tête-à-tête with Eoghan Cunnane

Get to know Eoghan Cunnane, one of the invited speakers to the upcoming 16th NYRA Meeting in Brussels (May 27th-29th), through this interview.  Dr Cunnane is a lecturer in Biomedical Engineering and Principal Investigator on an ERC Starting Grant at the University of Limerick. His research focuses on translational biomedical technology. When and why did you …

Read more

Green Connections: Exploring Cannabinoids and Male Fertility

While cannabis is the most widely used recreational drug in the world, the effects of phytocannabinoids on semen parameters and reproductive hormones remain controversial. It is composed of more than 400 chemicals, out of which approximately 100 are cannabinoids. A recent study by Dr. Zufferey and colleagues, published in Andrology, evaluated the impact of the …

Read more

ACROSIN deficiency identified as a cause of total fertilization failure and thus, male infertility in humans

In a most recent study, Hua and colleagues have identified a rare homozygous nonsense mutation in the ACR gene as a causative factor for male infertility, specifically leading to Total Fertilization Failure (TFF) during in vitro fertilization (IVF) attempts. The findings, published in Human Reproduction, shed light on the genetic basis of TFF, offering new …

Read more

Excessive mobile phone usage linked to potential decrease in sperm count

Over the last decades, mobile phones have become ubiquitously used regardless of people’s age, cultural background, gender, or geographical location. However, little is known about the impact on general fertility of the radiofrequency electromagnetic fields (RF-EMF) emitted by these devices, which can be absorbed by the human body. Specifically in the case of male fertility, …

Read more

Tête-à-tête with Brett Nixon

Through this interview, get the opportunity to meet the most international speaker of our next meeting, coming straight from Australia! Professor Brett Nixon is a Senior Research Fellow of the National Health and Medical Research Council of Australia and a Professor of Biology at The University of Newcastle, Australia. In this position, he serves as …

Read more

Tête-à-tête with Christophe Arnoult

You can now get a better knowledge on one of our speakers to the upcoming 15th NYRA Meeting in Caux (June 17th – 18th) through this ´tête-à-tête´. Prof. Christophe Arnoult obtained his PhD at the University of Grenoble Alpes where he is currently a head researcher at the Institute of Advanced Biosciences INSERM&CNRS (IAB). In …

Read more

Tête-à-tête with Pei-Hsuan Wu

Get to know another invited speaker to the upcoming 15th NYRA Meeting in Caux (June 17th-18th) through this interview.  Dr. Pei-Hsuan Wu conducted her Ph.D. research with Richard Carthew at Northwestern University in Evanston (Illinois, U.S.). After receiving her Ph.D. degree in 2013, she joined Phillip Zamore’s laboratory at the RNA Therapeutics Institute at the …

Read more

Tête-à-tête with Thomas Darde

Omics has been a hot topic in the 21st century; Genomics, transcriptomics, metabolomics, proteomics, lipidomics, etc. Nevertheless, omics hasn’t been without its challenges in terms of technical developments. For many scientists, the amount of data generated from most omics studies has been overwhelming. It has become indispensable in biology to have bioinformatic skills, which adds …

Read more

Childhood cancer and hematological disorders negatively affect spermatogonial quantity at diagnosis: a retrospective study of a male fertility preservation cohort

For young boys with cancer or a non-malignant hematological disorder, conditioning therapy, abdominal/pelvic radiotherapy, and certain chemotherapies form a major risk for germ cell loss. Contradictory studies have investigated the direct effects of such diseases on the development of the prepubertal male gonad before mainline treatment. For health professionals to counsel pediatric patients in the …

Read more

Temperature sensitivity of DNA double-strand break repair underpins heat-induced meiotic failure in mouse spermatogenesis

Kodai Hirano, Yuta Nonami, Yoshiaki Nakamura, Toshiyuki Sato, Takuya Sato, Keiichiro Ishiguro, Takehiko Ogawa, *Shosei Yoshida Background Spermatogenesis in mammals is a temperature-sensitive developmental process that occurs at a few degrees below the core body temperature of 38 °C. Elevated testis temperatures disrupt spermatogenesis at various phases, leading to male infertility. Artificial cryptorchidism, which involves surgically …

Read more

Tête-à-tête with Jan-Bernd Stukenborg

Get to know our first invited speaker to the upcoming 15th NYRA Meeting in Caux (June 17th-18th) through this ‘tête-à-tête’. Dr Stukenborg obtained his PhD at the Centre of Reproductive Medicine and Andrology (CeRA) in Münster, Germany, after which he joined the Karolinska Institutet for as a post-doctoral researcher. Currently Dr Stukenborg is a senior …

Read more

Global profiling of the proteomic changes associated with the post-testicular maturation of mouse spermatozoa

During the differentiation phase at the spermiogenesis (the last phase of the spermatogenesis), haploid round spermatids undergo an extreme morphological remodelling of nuclear and cytoplasmic structures. Nonetheless, while testicular sperm are morphologically specialized cells, they are not functional and lack both the ability to swim and fertilize. Hence, sperm maturation in the epididymis is therefore …

Read more

Molecular evolutionary investigation of spermatogenesis

Human semen quality is remarkably poor, with a reduced efficiency of spermatogenesis. Studies revealed that latter complex process has undergone rapid evolutionary changes. Male infertility is increasing which leads to a concomitant higher demand of assisted reproductive technologies. As other primates have not experienced the same decreasing fertility, a multicenter study sought to uncover the …

Read more

NYRA Session at ECA 2022

The 12th European Congress of Andrology took place from October 19th to October 21st in Barcelona, Spain, and once again NYRA  hosted a session with talks from selected younger researchers. Under the expert moderation of Alberto and Daniel from the NYRA board, Yoni Baert (Belgium) introduced us to testicular organoids and their potential in i.e., …

Read more

Summary of the 14th NYRA meeting

The 14th international NYRA meeting took place from September 20th to September 21st, 2022, in Norwich, United Kingdom. 31 participants from UK, Croatia, Spain, Denmark, Germany, Netherlands, France, Poland, and Belgium joined this meeting at the University of East Anglia (UEA), which is a part of the Norwich Research Park, one of Europe’s biggest communities of researchers in …

Read more

Single-cell roadmap of human gonadal development

After primordial germ cells (PGCs) have colonized the gonadal ridge at roughly 3–5 weeks post conception (WPC), two successive development stages are observed during male gonadogenesis: sex determination of the bipotential gonads and testis differentiation. At 6 WPC, the SRY gene becomes expressed in the bipotent supporting cells in the gonadal coelomic epithelium, ventral to …

Read more

Tête-à-tête with Simone Immler

To wrap up the ‘tête-à-tête’ series on speakers from the 14th NYRA Meeting in Norwich, we here present the tête-à-tête with Simone Immler. Simone Immler is a Professor of Genetics and Reproduction at the School of Biological Sciences at the University of East Anglia. Prof. Immler earned her MSc from the University of Basel, Switzerland, …

Read more

Tête-à-tête with Antoine Molaro

Get to know another invited speaker to the upcoming 14th NYRA Meeting in Norwich (September 19th-21st) through this ‘tête-à-tête’. Dr. Antoine Molaro studied Biology, did his Ph.D. at the Cold Spring Harbor Laboratory (NY, USA), and moved to Seattle (WA, USA) as Postdoctoral Fellow at Fred Hutchinson Cancer Research Center. Dr. Molaro is currently a …

Read more

Tête-à-tête with Sandra Laurentino

We bring you the opportunity to get to know another invited speaker to the upcoming 14th NYRA Meeting in Norwich (September 19th-21st) through this ‘tête-à-tête’. Dr. Sandra Laurentino studied Biochemistry and did her PhD in Biomedicine at the University of Beira Interior in her native Portugal. Right afterwards she move to Germany to  join the …

Read more

Tête-à-tête with Andrea Rippon

We bring you the opportunity to get to know another invited speaker to the upcoming 14th NYRA Meeting in Norwich (September 19th-21st) through this ‘tête-à-tête’. Andrea has over 20 years’ experience helping people build healthy mindsets and emotionally-intelligent relationships at work, home and school. She is a highly experienced trainer, a qualified Parent and Youth …

Read more

Generating sperm from 23 years old frozen stem cells

Testicular cryopreservation is an experimental method used to preserve gonadal tissue of pre-pubertal boys or men whose fertility is likely to be compromised due to chemotherapy treatment. A recent study on rats shows that viable sperm can be produced from cryopreserved spermatogonial stem cells (SSC) after 23 years of storage – a discovery that offers …

Read more

Tête-à-tête with Kristian Almstrup

This time we bring an interview to get to know another of our invited speakers at the 14th NYRA meeting, which will take place in Norwich from 19-21st of September 2022. Kristian Almstrup is a Senior Scientist at Copenhagen University Hospital – Rigshospitalet, where he serves as a research leader at the Department of Growth and Reproduction. …

Read more

Building functional sperm

Many thousands of genes are required for male fertility in mammals. In the testis, these genes govern the diverse individual processes of mitosis, meiosis and spermiogenesis, which are ultimately required to generate sperm. During this latter process of spermiogenesis, round spermatids undergo a complete remodelling to generate a sperm tail for motility, sculpt the nucleus …

Read more

Viable Offspring Derived From Single Unfertilized Mammalian Oocytes

The general understanding of fertilization is the fusion of two haploid gametes, the spermatozoon, and the oocyte, to form a diploid cell that goes through the multiple cell division and cell differentiation events of embryo development. However, recent research has pushed this understanding. Parthenogenesis, also known as virgin births, is another way of embryo development …

Read more

Single cell sequencing enables novel insights to unravel human testicular tissue heterogeneity

Testis tissue is very complex and heterogeneous as it is made up of several somatic (Leydig, Sertoli, peritubular myoid cells and others) and germ cell types (spermatogonia, spermatocytes and spermatids). Due to the high number of different cell types, histological and molecular studies have always been challenging. As an example, the use of bulk RNA …

Read more

World’s first approval for testicular re-implantation to restore fertility of childhood cancer survivors

Prof. Ellen Goossens from the Vrije Universiteit Brussel (VUB), in cooperation with the Universitair Ziekenhuis Brussel (UZ Brussel), received the ethical approval to re-implant previously frozen testicular tissue in male cancer survivors who lost their fertility because of childhood cancer treatments. If successful, sperm cells will develop in the implanted tissue to restorethe fertility ofthese patients. Childhood cancer survival rates …

Read more

COST Action ANDRONET

ANDRONET, the biggest running European network in andrology, aims to increase research collaboration, education, and public awareness in male reproductive health. It was born within a social context of worst reproductive outcomes, tightly related with the male factor, in which establishing strong connections between clinicians and researchers is essential to tackle a problem with such …

Read more

14th NYRA Meeting – SAVE THE DATES!

We are delighted to invite you to join us in the 14th NYRA Meeting taking place on September 19th-21st 2022, at University of East Anglia in Norwich in the United Kingdom. This last year has been a challenging time. The coronavirus pandemic has caused severe disruptions and obstacles to research as well as affected all …

Read more

13th NYRA Meeting – SAVE THE DATES!

Registration Abstract submission 13th NYRA Meeting: REGISTRATION IS NOW OPEN! Due to the COVID-19 worldwide situation, for the health and safety of the attendees, the 13th NYRA Meeting has been postponed to next May 29th-30th, 2021 and will take place as a Virtual Meeting. Don’t miss this opportunity to join the young researcher community! Submitting your …

Read more

Complete spermatogenesis in intratesticular testis tissue xenotransplants from immature non-human primate

Boys receiving gonadotoxic treatment (e.g. chemo- or radiotherapy) before puberty face the possibility of being infertile when they reach adulthood due to the loss of germ cells. As mature spermatozoa are not present, the only fertility preservation strategy currently offered involves the cryopreservation of immature testis tissue (ITT) containing spermatogonial stem cells (SSCs). Auto-transplantation of …

Read more

12th Meeting of the Network for Young Researchers in Andrology

By CONSTANZE MARESCH It is our great pleasure to announce the 12th NYRA Meeting, that will be held in Giessen, Germany, on September 23rd – 24th 2019. This year the meeting will be held adjacent to the 6th International Workshop on Molecular Andrology (https://www.uni-giessen.de/fbz/fb11/institute/anatomie/molandrol2019) and the 50th Anniversary of the Department of Urology in Giessen. …

Read more