Generating sperm from 23 years old frozen stem cells

Testicular cryopreservation is an experimental method used to preserve gonadal tissue of pre-pubertal boys or men whose fertility is likely to be compromised due to chemotherapy treatment. A recent study on rats shows that viable sperm can be produced from cryopreserved spermatogonial stem cells (SSC) after 23 years of storage – a discovery that offers …

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Building functional sperm

Many thousands of genes are required for male fertility in mammals. In the testis, these genes govern the diverse individual processes of mitosis, meiosis and spermiogenesis, which are ultimately required to generate sperm. During this latter process of spermiogenesis, round spermatids undergo a complete remodelling to generate a sperm tail for motility, sculpt the nucleus …

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13th NYRA Meeting – COVID-19 statement

Due to the COVID-19 worldwide situation, for the health and safety of the attendees, the 13th NYRA Meeting has been postponed to next May 29th-30th, 2021 and will take place as a Virtual Meeting. Don’t miss this opportunity to join the young researcher community! Stay tuned to our different channels for upcoming news! Registration will open …

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13th NYRA Meeting – SAVE THE DATES!

Registration Abstract submission 13th NYRA Meeting: REGISTRATION IS NOW OPEN! Due to the COVID-19 worldwide situation, for the health and safety of the attendees, the 13th NYRA Meeting has been postponed to next May 29th-30th, 2021 and will take place as a Virtual Meeting. Don’t miss this opportunity to join the young researcher community! Submitting your …

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First live birth after autologous testicular tissue grafting in rhesus macaques

Fertility preservation in young people before gonadotoxic therapies (for cancer or other diseases) is nowadays one of the most challenging issues in reproductive biology. However, interesting breakthroughs are bringing it closer to reality. As we commented in our last post, Dr. Goossens’ group achieved complete spermatogenesis in intratesticular testis tissue xenotransplants from immature non-human primates. …

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Complete spermatogenesis in intratesticular testis tissue xenotransplants from immature non-human primate

Boys receiving gonadotoxic treatment (e.g. chemo- or radiotherapy) before puberty face the possibility of being infertile when they reach adulthood due to the loss of germ cells. As mature spermatozoa are not present, the only fertility preservation strategy currently offered involves the cryopreservation of immature testis tissue (ITT) containing spermatogonial stem cells (SSCs). Auto-transplantation of …

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