Single-cell roadmap of human gonadal development

After primordial germ cells (PGCs) have colonized the gonadal ridge at roughly 3–5 weeks post conception (WPC), two successive development stages are observed during male gonadogenesis: sex determination of the bipotential gonads and testis differentiation. At 6 WPC, the SRY gene becomes expressed in the bipotent supporting cells in the gonadal coelomic epithelium, ventral to …

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Tête-à-tête with Simone Immler

To wrap up the ‘tête-à-tête’ series on speakers from the 14th NYRA Meeting in Norwich, we here present the tête-à-tête with Simone Immler. Simone Immler is a Professor of Genetics and Reproduction at the School of Biological Sciences at the University of East Anglia. Prof. Immler earned her MSc from the University of Basel, Switzerland, …

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Tête-à-tête with Antoine Molaro

Get to know another invited speaker to the upcoming 14th NYRA Meeting in Norwich (September 19th-21st) through this ‘tête-à-tête’. Dr. Antoine Molaro studied Biology, did his Ph.D. at the Cold Spring Harbor Laboratory (NY, USA), and moved to Seattle (WA, USA) as Postdoctoral Fellow at Fred Hutchinson Cancer Research Center. Dr. Molaro is currently a …

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Tête-à-tête with Sandra Laurentino

We bring you the opportunity to get to know another invited speaker to the upcoming 14th NYRA Meeting in Norwich (September 19th-21st) through this ‘tête-à-tête’. Dr. Sandra Laurentino studied Biochemistry and did her PhD in Biomedicine at the University of Beira Interior in her native Portugal. Right afterwards she move to Germany to  join the …

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Tête-à-tête with Andrea Rippon

We bring you the opportunity to get to know another invited speaker to the upcoming 14th NYRA Meeting in Norwich (September 19th-21st) through this ‘tête-à-tête’. Andrea has over 20 years’ experience helping people build healthy mindsets and emotionally-intelligent relationships at work, home and school. She is a highly experienced trainer, a qualified Parent and Youth …

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Generating sperm from 23 years old frozen stem cells

Testicular cryopreservation is an experimental method used to preserve gonadal tissue of pre-pubertal boys or men whose fertility is likely to be compromised due to chemotherapy treatment. A recent study on rats shows that viable sperm can be produced from cryopreserved spermatogonial stem cells (SSC) after 23 years of storage – a discovery that offers …

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Tête-à-tête with Kristian Almstrup

This time we bring an interview to get to know another of our invited speakers at the 14th NYRA meeting, which will take place in Norwich from 19-21st of September 2022. Kristian Almstrup is a Senior Scientist at Copenhagen University Hospital – Rigshospitalet, where he serves as a research leader at the Department of Growth and Reproduction. …

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Building functional sperm

Many thousands of genes are required for male fertility in mammals. In the testis, these genes govern the diverse individual processes of mitosis, meiosis and spermiogenesis, which are ultimately required to generate sperm. During this latter process of spermiogenesis, round spermatids undergo a complete remodelling to generate a sperm tail for motility, sculpt the nucleus …

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