Blog - Page 2 of 10

Global profiling of the proteomic changes associated with the post-testicular maturation of mouse spermatozoa

2023-02-20 by Alberto de la Iglesia

During the differentiation phase at the spermiogenesis (the last phase of the spermatogenesis), haploid round spermatids undergo an extreme morphological remodelling of nuclear and cytoplasmic structures. Nonetheless, while testicular sperm are morphologically specialized cells, they are not functional and lack both the ability to swim and fertilize. Hence, sperm maturation in the epididymis is therefore …

Molecular evolutionary investigation of spermatogenesis

2023-02-06 by Gülizar Saritas

Human semen quality is remarkably poor, with a reduced efficiency of spermatogenesis. Studies revealed that latter complex process has undergone rapid evolutionary changes. Male infertility is increasing which leads to a concomitant higher demand of assisted reproductive technologies. As other primates have not experienced the same decreasing fertility, a multicenter study sought to uncover the …

NYRA Session at ECA 2022

2022-12-30 by Alberto de la Iglesia

The 12th European Congress of Andrology took place from October 19th to October 21st in Barcelona, Spain, and once again NYRA hosted a session with talks from selected younger researchers. Under the expert moderation of Alberto and Daniel from the NYRA board, Yoni Baert (Belgium) introduced us to testicular organoids and their potential in i.e., …

Identification of protein facilitating gamete fusion

2022-12-132022-12-12 by Daniel Marcu

Gamete fusion is the union of two haploid cells (sperm and egg) resulting in fertilisation and embryo development. In mice, this fundamental process is depended on the presence of the egg receptor on the sperm membrane (IZUMO1) and the sperm receptor on the egg membrane (JUNO). While the relevance of this sperm-egg receptors interaction is …

Summary of the 14th NYRA meeting

2022-12-122022-11-08 by Daniel Marcu

The 14th international NYRA meeting took place from September 20th to September 21st, 2022, in Norwich, United Kingdom. 31 participants from UK, Croatia, Spain, Denmark, Germany, Netherlands, France, Poland, and Belgium joined this meeting at the University of East Anglia (UEA), which is a part of the Norwich Research Park, one of Europe’s biggest communities of researchers in …

Single-cell roadmap of human gonadal development

2022-11-072022-11-07 by Guillaume Richer

After primordial germ cells (PGCs) have colonized the gonadal ridge at roughly 3–5 weeks post conception (WPC), two successive development stages are observed during male gonadogenesis: sex determination of the bipotential gonads and testis differentiation. At 6 WPC, the SRY gene becomes expressed in the bipotent supporting cells in the gonadal coelomic epithelium, ventral to …

Tête-à-tête with Simone Immler

2022-11-04 by Dorte

To wrap up the ‘tête-à-tête’ series on speakers from the 14th NYRA Meeting in Norwich, we here present the tête-à-tête with Simone Immler. Simone Immler is a Professor of Genetics and Reproduction at the School of Biological Sciences at the University of East Anglia. Prof. Immler earned her MSc from the University of Basel, Switzerland, …

Tête-à-tête with Antoine Molaro

2022-09-17 by Alberto de la Iglesia

Get to know another invited speaker to the upcoming 14th NYRA Meeting in Norwich (September 19th-21st) through this ‘tête-à-tête’. Dr. Antoine Molaro studied Biology, did his Ph.D. at the Cold Spring Harbor Laboratory (NY, USA), and moved to Seattle (WA, USA) as Postdoctoral Fellow at Fred Hutchinson Cancer Research Center. Dr. Molaro is currently a …

Tête-à-tête with Sandra Laurentino

2022-08-05 by Sven Berres

We bring you the opportunity to get to know another invited speaker to the upcoming 14th NYRA Meeting in Norwich (September 19th-21st) through this ‘tête-à-tête’. Dr. Sandra Laurentino studied Biochemistry and did her PhD in Biomedicine at the University of Beira Interior in her native Portugal. Right afterwards she move to Germany to join the …

Tête-à-tête with Andrea Rippon

2022-09-172022-07-21 by Daniel Marcu

We bring you the opportunity to get to know another invited speaker to the upcoming 14th NYRA Meeting in Norwich (September 19th-21st) through this ‘tête-à-tête’. Andrea has over 20 years’ experience helping people build healthy mindsets and emotionally-intelligent relationships at work, home and school. She is a highly experienced trainer, a qualified Parent and Youth …