Tête-à-tête with Christophe Arnoult

You can now get a better knowledge on one of our speakers to the upcoming 15th NYRA Meeting in Caux (June 17th – 18th) through this ´tête-à-tête´. Prof. Christophe Arnoult obtained his PhD at the University of Grenoble Alpes where he is currently a head researcher at the Institute of Advanced Biosciences INSERM&CNRS (IAB). In …

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Tête-à-tête with Pei-Hsuan Wu

Get to know another invited speaker to the upcoming 15th NYRA Meeting in Caux (June 17th-18th) through this interview.  Dr. Pei-Hsuan Wu conducted her Ph.D. research with Richard Carthew at Northwestern University in Evanston (Illinois, U.S.). After receiving her Ph.D. degree in 2013, she joined Phillip Zamore’s laboratory at the RNA Therapeutics Institute at the …

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Tête-à-tête with Thomas Darde

Omics has been a hot topic in the 21st century; Genomics, transcriptomics, metabolomics, proteomics, lipidomics, etc. Nevertheless, omics hasn’t been without its challenges in terms of technical developments. For many scientists, the amount of data generated from most omics studies has been overwhelming. It has become indispensable in biology to have bioinformatic skills, which adds …

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Childhood cancer and hematological disorders negatively affect spermatogonial quantity at diagnosis: a retrospective study of a male fertility preservation cohort

For young boys with cancer or a non-malignant hematological disorder, conditioning therapy, abdominal/pelvic radiotherapy, and certain chemotherapies form a major risk for germ cell loss. Contradictory studies have investigated the direct effects of such diseases on the development of the prepubertal male gonad before mainline treatment. For health professionals to counsel pediatric patients in the …

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Temperature sensitivity of DNA double-strand break repair underpins heat-induced meiotic failure in mouse spermatogenesis

Kodai Hirano, Yuta Nonami, Yoshiaki Nakamura, Toshiyuki Sato, Takuya Sato, Keiichiro Ishiguro, Takehiko Ogawa, *Shosei Yoshida Background Spermatogenesis in mammals is a temperature-sensitive developmental process that occurs at a few degrees below the core body temperature of 38 °C. Elevated testis temperatures disrupt spermatogenesis at various phases, leading to male infertility. Artificial cryptorchidism, which involves surgically …

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Tête-à-tête with Jan-Bernd Stukenborg

Get to know our first invited speaker to the upcoming 15th NYRA Meeting in Caux (June 17th-18th) through this ‘tête-à-tête’. Dr Stukenborg obtained his PhD at the Centre of Reproductive Medicine and Andrology (CeRA) in Münster, Germany, after which he joined the Karolinska Institutet for as a post-doctoral researcher. Currently Dr Stukenborg is a senior …

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Global profiling of the proteomic changes associated with the post-testicular maturation of mouse spermatozoa

During the differentiation phase at the spermiogenesis (the last phase of the spermatogenesis), haploid round spermatids undergo an extreme morphological remodelling of nuclear and cytoplasmic structures. Nonetheless, while testicular sperm are morphologically specialized cells, they are not functional and lack both the ability to swim and fertilize. Hence, sperm maturation in the epididymis is therefore …

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Molecular evolutionary investigation of spermatogenesis

Human semen quality is remarkably poor, with a reduced efficiency of spermatogenesis. Studies revealed that latter complex process has undergone rapid evolutionary changes. Male infertility is increasing which leads to a concomitant higher demand of assisted reproductive technologies. As other primates have not experienced the same decreasing fertility, a multicenter study sought to uncover the …

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NYRA Session at ECA 2022

The 12th European Congress of Andrology took place from October 19th to October 21st in Barcelona, Spain, and once again NYRA  hosted a session with talks from selected younger researchers. Under the expert moderation of Alberto and Daniel from the NYRA board, Yoni Baert (Belgium) introduced us to testicular organoids and their potential in i.e., …

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