Temperature sensitivity of DNA double-strand break repair underpins heat-induced meiotic failure in mouse spermatogenesis

Kodai Hirano, Yuta Nonami, Yoshiaki Nakamura, Toshiyuki Sato, Takuya Sato, Keiichiro Ishiguro, Takehiko Ogawa, *Shosei Yoshida Background Spermatogenesis in mammals is a temperature-sensitive developmental process that occurs at a few degrees below the core body temperature of 38 °C. Elevated testis temperatures disrupt spermatogenesis at various phases, leading to male infertility. Artificial cryptorchidism, which involves surgically …

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Single-cell roadmap of human gonadal development

After primordial germ cells (PGCs) have colonized the gonadal ridge at roughly 3–5 weeks post conception (WPC), two successive development stages are observed during male gonadogenesis: sex determination of the bipotential gonads and testis differentiation. At 6 WPC, the SRY gene becomes expressed in the bipotent supporting cells in the gonadal coelomic epithelium, ventral to …

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World’s first approval for testicular re-implantation to restore fertility of childhood cancer survivors

Prof. Ellen Goossens from the Vrije Universiteit Brussel (VUB), in cooperation with the Universitair Ziekenhuis Brussel (UZ Brussel), received the ethical approval to re-implant previously frozen testicular tissue in male cancer survivors who lost their fertility because of childhood cancer treatments. If successful, sperm cells will develop in the implanted tissue to restorethe fertility ofthese patients. Childhood cancer survival rates …

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