13th NYRA Meeting – SAVE THE DATES!

Dear NYRA member,  The 13th NYRA Meeting will be held in Sant Feliu de Guíxols, Girona, Spain, next May 9th-10th 2020, preceding the 21st European Testis Workshop (ETW). Both the NYRA Meeting and the ETW will take place at the Eden Roc Hotel, in the heart of the wonderful Costa Brava. So save the dates and join us! Run and take a look at the NYRA2020 Official Webpage for further details.  And do not miss this information! The 21st ETW will take Read more…

Complete spermatogenesis in intratesticular testis tissue xenotransplants from immature non-human primate

Boys receiving gonadotoxic treatment (e.g. chemo- or radiotherapy) before puberty face the possibility of being infertile when they reach adulthood due to the loss of germ cells. As mature spermatozoa are not present, the only fertility preservation strategy currently offered involves the cryopreservation of immature testis tissue (ITT) containing spermatogonial stem cells (SSCs). Auto-transplantation of cryopreserved ITT has the advantage of retaining SSCs within their niche, providing an optimal microenvironment, and is therefore a promising Read more…

Tête-a-tête with Nils Lambalk

By Tiina Lehtiniemi The man in the editor’s chair The Dutch gynaecologist Nils Lambalk took over as editor-in-chief of Human Reproduction early this year. He is a gynaecologist and fertility specialist with focus on reproductive endocrinology. He has published over 100 papers and book chapters on subjects related to his research interests. We asked him to tell us a little bit about himself, his career and to share advice to young researchers. Here’s how he Read more…

Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia

By MANON OUD Approximately 1 in 6 couples is unable to conceive after one year of unprotected sexual intercourse. In roughly half of all infertility cases there is a male factor involved. Considered predominantly a genetic condition, currently the majority of patients with a severe form of infertility remains unexplained. Recently, Whitfield et al. discovered a new gene associated with isolated asthenozoospermia (immotile sperm), which was published in the American Journal of Human Genetics. Structural Read more…

Tête-a-tête with Kyle Orwig

This time we bring an interview with the leader behind the group that recently published in Science the successful birth of Grady, the first rhesus macaque born after an autologous graft of immature testicular tissue. Professor Kyle Orwig obtained his PhD from Oregon State University in 1994. Afterwards, he completed postdoctoral training at the University of Kansas Medical Center and, in 1999, became assistant professor at the University of Pennsylvania. Nowadays, Dr Orwig is a Read more…

First live birth after autologous testicular tissue grafting in rhesus macaques

Fertility preservation in young people before gonadotoxic therapies (for cancer or other diseases) is nowadays one of the most challenging issues in reproductive biology. However, interesting breakthroughs are bringing it closer to reality. As we commented in our last post, Dr. Goossens’ group achieved complete spermatogenesis in intratesticular testis tissue xenotransplants from immature non-human primates. This time we would like to highlight the outstanding Science paper from Dr. Orwig’s laboratory, from the Magee-Womens Research Institute Read more…