Tête-a-tête with Kyle Orwig

This time we bring an interview with the leader behind the group that recently published in Science the successful birth of Grady, the first rhesus macaque born after an autologous graft of immature testicular tissue. Professor Kyle Orwig obtained his PhD from Oregon State University in 1994. Afterwards, he completed postdoctoral training at the University of Kansas Medical Center and, in 1999, became assistant professor at the University of Pennsylvania. Nowadays, Dr Orwig is a Read more…

First live birth after autologous testicular tissue grafting in rhesus macaques

Fertility preservation in young people before gonadotoxic therapies (for cancer or other diseases) is nowadays one of the most challenging issues in reproductive biology. However, interesting breakthroughs are bringing it closer to reality. As we commented in our last post, Dr. Goossens’ group achieved complete spermatogenesis in intratesticular testis tissue xenotransplants from immature non-human primates. This time we would like to highlight the outstanding Science paper from Dr. Orwig’s laboratory, from the Magee-Womens Research Institute Read more…

Complete spermatogenesis in intratesticular testis tissue xenotransplants from immature non-human primate

Boys receiving gonadotoxic treatment (e.g. chemo- or radiotherapy) before puberty face the possibility of being infertile when they reach adulthood due to the loss of germ cells. As mature spermatozoa are not present, the only fertility preservation strategy currently offered involves the cryopreservation of immature testis tissue (ITT) containing spermatogonial stem cells (SSCs). Auto-transplantation of cryopreserved ITT has the advantage of retaining SSCs within their niche, providing an optimal microenvironment, and is therefore a promising Read more…