Paper Archives

Variant PNLDC1, Defective piRNA Processing, and Azoospermia

2021-09-082021-08-17 by Manon Oud

By MANON OUD Approximately 1% of all men fail to produce sperm at all. In a recent publication in the New England Journal of Medicine, Nagirnaja and Mørup et al. demonstrate one of the causes for such complete lack of sperm production, which is called non-obstructive azoospermia. The results point to a direct mechanistic effect …

Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia

2021-09-082019-10-29 by Manon Oud

By MANON OUD Approximately 1 in 6 couples is unable to conceive after one year of unprotected sexual intercourse. In roughly half of all infertility cases there is a male factor involved. Considered predominantly a genetic condition, currently the majority of patients with a severe form of infertility remains unexplained. Recently, Whitfield et al. discovered …

First live birth after autologous testicular tissue grafting in rhesus macaques

2022-02-212019-05-08 by Alberto de la Iglesia

Fertility preservation in young people before gonadotoxic therapies (for cancer or other diseases) is nowadays one of the most challenging issues in reproductive biology. However, interesting breakthroughs are bringing it closer to reality. As we commented in our last post, Dr. Goossens’ group achieved complete spermatogenesis in intratesticular testis tissue xenotransplants from immature non-human primates. …

Complete spermatogenesis in intratesticular testis tissue xenotransplants from immature non-human primate

2021-09-082019-03-27 by borgmanj

Boys receiving gonadotoxic treatment (e.g. chemo- or radiotherapy) before puberty face the possibility of being infertile when they reach adulthood due to the loss of germ cells. As mature spermatozoa are not present, the only fertility preservation strategy currently offered involves the cryopreservation of immature testis tissue (ITT) containing spermatogonial stem cells (SSCs). Auto-transplantation of …

A novel atypical sperm centriole is functional during human fertilization

2021-09-082019-01-07 by Dorte

The centriole is a microtubule-based organelle and typically consists of nine sets of short microtubule triplets arranged in a cylindrical structure. The centriole is surrounded by a special matrix, the pericentriolar matrix (PCM).

Neonatal testis growthrecreated in vitro by two-dimensionalorgan-spreading

2021-09-082018-11-07 by ccmaresch

Since the beginning of the 20th century, attempts have been made to differentiate male germ cells into mature spermatozoa in culture

Environmental levels of triclosan and male fertility

2021-09-082018-01-16 by tdarde

Press Highlights Triclosan (2,4,4’-tricloro-2’-hydroxy-diphenyl ether) is a synthetic compound classified both as a drug and a pesticide. It is widely used in consumer goods for its broad-spectrum antimicrobial properties. At low doses, triclosan impairs bacterial growth by inhibiting enoyl-acyl carrier protein reductase, an enzyme necessary for bacterial lipid biosynthesis, while at high doses, triclosan is …