First live birth after autologous testicular tissue grafting in rhesus macaques

Fertility preservation in young people before gonadotoxic therapies (for cancer or other diseases) is nowadays one of the most challenging issues in reproductive biology. However, interesting breakthroughs are bringing it closer to reality. As we commented in our last post, Dr. Goossens’ group achieved complete spermatogenesis in intratesticular testis tissue xenotransplants from immature non-human primates. …

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Complete spermatogenesis in intratesticular testis tissue xenotransplants from immature non-human primate

Boys receiving gonadotoxic treatment (e.g. chemo- or radiotherapy) before puberty face the possibility of being infertile when they reach adulthood due to the loss of germ cells. As mature spermatozoa are not present, the only fertility preservation strategy currently offered involves the cryopreservation of immature testis tissue (ITT) containing spermatogonial stem cells (SSCs). Auto-transplantation of …

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12th Meeting of the Network for Young Researchers in Andrology

By CONSTANZE MARESCH It is our great pleasure to announce the 12th NYRA Meeting, that will be held in Giessen, Germany, on September 23rd – 24th 2019. This year the meeting will be held adjacent to the 6th International Workshop on Molecular Andrology (https://www.uni-giessen.de/fbz/fb11/institute/anatomie/molandrol2019) and the 50th Anniversary of the Department of Urology in Giessen. …

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Accuracy of human sperm DNA oxidation quantification and threshold determination using an 8-OHdG immuno-detection assay

Accuracy of human sperm DNA oxidation quantification and threshold determination using an 8-OHdG immuno-detection assay Vorilhon S et al. – Hum Reprod. 2018 Apr 1;33(4):553-562. doi: 10.1093/humrep/dey038 Of factors contributing to sperm DNA damage, oxidative stress is recognized as one of the major contributing causes to sperm cell dysfunction. Caused by elevated levels of intracellular …

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First time in vitro maturation of oocytes from human primordial follicles

Currently, couples going through In vitro fertilisation (IVF) require the treatment of women with hormones for ovarian stimulation in order to stimulate simultaneously growth of several follicles and to maximize a large number of oocytes available IVF. However, this treatment can have several side-effects and it is not suitable for every woman. This is especially …

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