We are excited to introduce Dr. Erika Matunis, a speaker at the 17th NYRA Meeting. Dr. Matunis is a Professor of Cell Biology at the Johns Hopkins University School of Medicine, where her research explores how stem cells renew and differentiate. Her work uses the fruit fly testis as a model to study the molecular signals that regulate the proliferation and differentiation of germline stem cells into sperm. Recently, her team discovered that cells transitioning into sperm can be redirected back into stem cells. Dr. Matunis’ current research focuses on how spermatogonia can reverse differentiation and become germline stem cells once again.
1. When and why did you decide to work in the field of reproductive biology?
As a doctoral student I studied heterogeneous nuclear ribonucleoproteins (hnRNPs) with Gideon Dreyfuss. The lab’s strengths of the were in biochemistry and cell biology, and while studying hnRNP function, I became very interested in moving to a genetic model system as a postdoctoral fellow. I was also fascinated by stem cells and wanted to work in a relatively new field. Joining Steve DiNardo’s lab at Rockefeller was a perfect match. They had just started to study stem cells in Drosophila melanogaster, focusing on the testis. This is how I entered the field of reproductive biology.
- Could you share a moment of challenge in your career, and the lessons you learned from it?
This career brings more joy than frustration. However, reviewers’ comments can be particularly challenging. Venting is crucial when your work is misunderstood. Having a partner who’s also a scientist provides an excellent sounding board. I channel my initial reaction into a draft response I later revise extensively. This allows the emotional phase to pass before I can objectively consider the critiques.
- What has been the greatest success in your career so far?
I was very fortunate early in my career to lead one of the first teams to characterize an adult stem cell niche at the cellular and molecular level. We built on that initial finding by discovering several other conserved features of stem cell niches, including the ability of differentiating cells to reverse their fate and dedifferentiate into stem cells. However, the greatest success in my career has been the privilege of mentoring many young scientists at all levels. These talented individuals have truly shaped our research, making it what it is today while enriching our research environment immeasurably.
- What advice would you give to young researchers?
Every young researcher’s experiences shape them into a unique individual. It is crucial to listen attentively to each person’s aspirations, examine potential barriers on their path to their desired career, and work towards removing these obstacles or adjusting the path accordingly. Having a team of supportive mentors and coaches significantly strengthens this process. Your mentors should always prioritize your growth and development, putting your interests first.